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Query: NC_017379:996500:1011379 Helicobacter pylori Puno135 chromosome, complete genome

Start: 1011379, End: 1012731, Length: 1353

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011206:2447905:2459868245986824620872220Acidithiobacillus ferrooxidans ATCC 53993, complete genomeDNA topoisomerase type IA zn finger domain protein1e-1274.7
NC_017068:1450049:1450049145004914514851437Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein2e-39163
NC_011761:2546081:2558152255815225602632112Acidithiobacillus ferrooxidans ATCC 23270 chromosome, completehypothetical protein1e-1274.7
NC_009778:1717458:1722846172284617243451500Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein2e-0861.2
NC_008757:111292:1306141306141320411428Polaromonas naphthalenivorans CJ2 plasmid pPNAP01, completeprotein kinase2e-30134
NC_017355:997089:1013018101301810143791362Helicobacter pylori v225d chromosome, complete genomeprotein kinase C-like protein0874
NC_012108:1694817:1694817169481716962741458Desulfobacterium autotrophicum HRM2, complete genomeputative kinase8e-28125
NC_010170:4463000:4502476450247645038191344Bordetella petrii, complete genomeputative protein kinase6e-52205
NC_006625:144929:1632941632941647931500Klebsiella pneumoniae NTUH-K2044 plasmid pK2044, complete sequenceputative protein kinase2e-0963.9
NC_017362:992293:1003208100320810044191212Helicobacter pylori Lithuania75 chromosome, complete genomeputative serine/threonine kinase0725
NC_012973:967380:9807869807869821351350Helicobacter pylori B38 chromosome, complete genomeserine/threonine kinase0869
NC_017378:986611:1001474100147410028291356Helicobacter pylori Puno120 chromosome, complete genomeserine/threonine kinase0895
NC_016940:271500:2891212891212911962076Saprospira grandis str. Lewin chromosome, complete genomeserine/threonine protein kinase1e-0758.2
NC_013410:2691437:2704709270470927061541446Fibrobacter succinogenes subsp. succinogenes S85 chromosome,serine/threonine protein kinase3e-24113
NC_010002:4572573:4592579459257945939221344Delftia acidovorans SPH-1, complete genomeserine/threonine protein kinase6e-52205