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Query: NC_017379:996500:1006377 Helicobacter pylori Puno135 chromosome, complete genome

Start: 1006377, End: 1008158, Length: 1782

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017378:986611:9964459964459982531809Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein0907
NC_017355:997089:1007901100790110092471347Helicobacter pylori v225d chromosome, complete genomehypothetical protein0667
NC_000915:453958:4667574667574681751419Helicobacter pylori 26695, complete genomehypothetical protein2e-175615
NC_012973:967380:9771909771909807923603Helicobacter pylori B38 chromosome, complete genomehypothetical protein1e-150533
NC_000915:453958:466124466124466510387Helicobacter pylori 26695, complete genomehypothetical protein2e-40167
NC_017355:997089:100939610093961009680285Helicobacter pylori v225d chromosome, complete genomehypothetical protein5e-26119