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Query: NC_017379:996500:1001101 Helicobacter pylori Puno135 chromosome, complete genome

Start: 1001101, End: 1004172, Length: 3072

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017355:997089:1002449100244910056343186Helicobacter pylori v225d chromosome, complete genomehypothetical protein01793
NC_018939:454000:4703454703454734103066Helicobacter pylori 26695 chromosome, complete genomehypothetical protein01656
NC_000915:453958:4703404703404734053066Helicobacter pylori 26695, complete genomehypothetical protein01656
NC_012973:967380:9735589735589750271470Helicobacter pylori B38 chromosome, complete genome0832
NC_012973:967380:9719249719249735191596Helicobacter pylori B38 chromosome, complete genome0773
NC_017362:992293:9995379995371000253717Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein2e-118427
NC_010002:4572573:4581297458129745846323336Delftia acidovorans SPH-1, complete genomeCold-shock protein DNA-binding4e-1997.8
NC_017068:1450049:1459731145973114636393909Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein3e-0965.1