Pre_GI: BLASTP Hits

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Query: NC_017379:505350:524641 Helicobacter pylori Puno135 chromosome, complete genome

Start: 524641, End: 524820, Length: 180

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017358:563336:581783581783581962180Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein2e-24110
NC_017355:493237:512484512484512672189Helicobacter pylori v225d chromosome, complete genomeaspartyl/glutamyl-tRNA amidotransferase subunit B5e-24109
NC_017378:502806:521742521742521936195Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein8e-24108
NC_010698:819912:825192825192825374183Helicobacter pylori Shi470, complete genomehypothetical protein8e-22102
NC_011333:514464:535835535835536014180Helicobacter pylori G27 chromosome, complete genomehypothetical protein2e-1064.3
NC_017063:800156:820059820059820238180Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein1e-0961.6