Pre_GI: BLASTP Hits

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Query: NC_017379:1035464:1056695 Helicobacter pylori Puno135 chromosome, complete genome

Start: 1056695, End: 1056955, Length: 261

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017367:278916:287337287337287597261Helicobacter pylori F57, complete genomevirB3 type IV secretion protein1e-40165
NC_017358:220900:230864230864231124261Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein1e-40165
NC_011333:1040192:104873510487351048995261Helicobacter pylori G27 chromosome, complete genomehypothetical protein1e-40164
NC_018939:454000:461755461755462021267Helicobacter pylori 26695 chromosome, complete genomehypothetical protein4e-1890.1
NC_000915:453958:461749461749462015267Helicobacter pylori 26695, complete genomehypothetical protein4e-1890.1
NC_014555:1526775:154006615400661540332267Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein4e-1889.7
NC_011498:448000:489522489522489788267Helicobacter pylori P12, complete genomeVirB3 type IV secretion protein5e-1889.7
NC_017361:1528239:153036515303651530631267Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein2e-1787.8
NC_015674:1562968:157445015744501574713264Helicobacter bizzozeronii CIII-1, complete genomehypothetical protein8e-0959.3
NC_005090:1033746:105668510566851056930246Wolinella succinogenes DSM 1740, complete genomehypothetical protein3e-0857.4
NC_017063:834674:840412840412840675264Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein1e-0755.5
NC_014256:485969:524861524861525124264Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-0755.5
NC_011498:1391788:139661913966191396882264Helicobacter pylori P12, complete genomeVirB3 type IV secretion protein1e-0755.5
NC_017366:1055319:105989910598991060162264Helicobacter pylori F32, complete genomehypothetical protein1e-0755.5