Pre_GI: BLASTP Hits

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Query: NC_017379:1035464:1047734 Helicobacter pylori Puno135 chromosome, complete genome

Start: 1047734, End: 1047997, Length: 264

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017358:220900:239807239807240070264Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein2e-2098.2
NC_011498:448000:480368480368480631264Helicobacter pylori P12, complete genomehypothetical protein2e-2098.2
NC_010698:870312:901624901624901887264Helicobacter pylori Shi470, complete genomehypothetical protein2e-2098.2
NC_017376:57500:883958839588658264Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein2e-2097.8
NC_014555:1526775:154920815492081549471264Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein7e-2095.9
NC_017367:278916:296283296283296546264Helicobacter pylori F57, complete genomehypothetical protein2e-1994.7
NC_017357:973392:985606985606985869264Helicobacter pylori 908 chromosome, complete genomehypothetical protein3e-1994
NC_017374:974279:986493986493986756264Helicobacter pylori 2017 chromosome, complete genomehypothetical protein3e-1994
NC_017381:982216:994448994448994711264Helicobacter pylori 2018 chromosome, complete genomehypothetical protein3e-1994
NC_017361:930280:961542961542961805264Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein5e-1992.8
NC_014256:448710:464365464365464628264Helicobacter pylori B8 chromosome, complete genomehypothetical protein7e-1992.4
NC_017371:1030148:104088210408821041145264Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein4e-1890.1