Pre_GI: BLASTP Hits

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Query: NC_017379:1035464:1045201 Helicobacter pylori Puno135 chromosome, complete genome

Start: 1045201, End: 1045758, Length: 558

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017358:220900:242047242047242604558Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein5e-88323
NC_010698:870312:899090899090899647558Helicobacter pylori Shi470, complete genomehypothetical protein9e-88322
NC_017367:278916:298522298522299079558Helicobacter pylori F57, complete genomehypothetical protein2e-87321
NC_011333:1040192:105991810599181060475558Helicobacter pylori G27 chromosome, complete genomehypothetical protein2e-87321
NC_017361:930280:959008959008959565558Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein1e-85315
NC_014555:1526775:155144815514481552005558Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein2e-85315
NC_017371:1030148:104312210431221043679558Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein4e-85313
NC_017376:57500:858658586586422558Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein7e-85312
NC_017374:974279:988732988732989289558Helicobacter pylori 2017 chromosome, complete genomehypothetical protein2e-84310
NC_017381:982216:996687996687997244558Helicobacter pylori 2018 chromosome, complete genomehypothetical protein2e-84310
NC_017357:973392:987845987845988402558Helicobacter pylori 908 chromosome, complete genomehypothetical protein4e-83306
NC_011498:448000:477879477879478391513Helicobacter pylori P12, complete genomehypothetical protein2e-78291
NC_017361:1528239:1543901154390115460332133Helicobacter pylori SouthAfrica7 chromosome, complete genomeconjugal transfer protein (traG)4e-1271.2
NC_017063:834674:8517278517278539702244Helicobacter pylori ELS37 chromosome, complete genomeVirD4 coupling protein1e-1066.2
NC_017372:748097:7818747818747841262253Helicobacter pylori India7 chromosome, complete genomeVirD4 coupling protein2e-1065.5
NC_011498:1391788:1408783140878314110262244Helicobacter pylori P12, complete genomeVirD4 coupling protein2e-0962
NC_017371:1470582:1505340150534015072441905Helicobacter pylori Gambia94/24 chromosome, complete genomeVirD4 coupling protein3e-0651.6
NC_014256:485969:5108335108335129622130Helicobacter pylori B8 chromosome, complete genometype IV secretion system protein VirD45e-0650.8