Pre_GI: BLASTP Hits

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Query: NC_017379:1035464:1042917 Helicobacter pylori Puno135 chromosome, complete genome

Start: 1042917, End: 1043198, Length: 282

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017367:278916:301112301112301393282Helicobacter pylori F57, complete genomehypothetical protein2e-46184
NC_017358:220900:244607244607244888282Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein2e-46184
NC_010698:870312:896806896806897087282Helicobacter pylori Shi470, complete genomehypothetical protein2e-46184
NC_011498:448000:475560475560475841282Helicobacter pylori P12, complete genomehypothetical protein2e-46184
NC_014555:1526775:155426615542661554547282Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein2e-46183
NC_017361:930280:956844956844957125282Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein4e-46182
NC_017376:57500:835348353483815282Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein1e-45181
NC_017357:973392:990385990385990519135Helicobacter pylori 908 chromosome, complete genomehypothetical protein4e-1786.7
NC_017371:1030148:104567310456731045807135Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein4e-1786.7
NC_017374:974279:991272991272991406135Helicobacter pylori 2017 chromosome, complete genomehypothetical protein4e-1786.7
NC_017381:982216:999227999227999361135Helicobacter pylori 2018 chromosome, complete genomehypothetical protein4e-1786.7
NC_002967:552000:558257558257558538282Treponema denticola ATCC 35405, complete genomehypothetical protein1e-1271.6
NC_011662:2402408:242444224244422424690249Thauera sp. MZ1T, complete genomeaddiction module toxin, RelE/StbE family2e-1168.2
NC_016630:434500:439306439306439584279Filifactor alocis ATCC 35896 chromosome, complete genometoxin-antitoxin system, toxin component, RelE family3e-1167.4
NC_013416:1091432:110934811093481109614267Aggregatibacter actinomycetemcomitans D11S-1, complete genomeaddiction module antitoxin/putative RelE toxin-like protein, plasmid stabilization system5e-1166.6
NC_016513:1400899:142004314200431420309267Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completeaddiction module antitoxin4e-1166.6
NC_011830:3786173:379952037995203799792273Desulfitobacterium hafniense DCB-2, complete genomeaddiction module toxin, RelE/StbE family9e-1165.5
NC_017068:1852708:187315518731551873430276Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative addiction module toxin1e-1065.1
NC_013165:1294000:129938412993841299665282Slackia heliotrinireducens DSM 20476, complete genomeaddiction module toxin, RelE/StbE family2e-1064.7
NC_012846:1147000:116049611604961160777282Bartonella grahamii as4aup, complete genomeaddiction module toxin, RelE/StbE family5e-1063.2
NC_015385:1875671:190920219092021909492291Treponema succinifaciens DSM 2489 chromosome, complete genomeaddiction module toxin, RelE/StbE family6e-1062.8
NC_009802:1977596:199350019935001993769270Campylobacter concisus 13826, complete genomeaddiction module toxin, RelE/StbE family8e-1062.4
NC_011992:2279752:230373823037382304019282Acidovorax ebreus TPSY, complete genomeaddiction module toxin, RelE/StbE family1e-0961.6
NC_013316:2033906:205562320556232055913291Clostridium difficile R20291, complete genomeaddiction module toxin, rele/stbe family2e-0960.8
NC_016945:324519:327985327985328254270Vibrio cholerae IEC224 chromosome II, complete sequenceplasmid stabilization system protein3e-0960.8
NC_016446:49618:530835308353379297Vibrio cholerae O1 str. 2010EL-1786 chromosome 2, completeplasmid stabilization system protein3e-0960.5
NC_002506:324552:328018328018328314297Vibrio cholerae O1 biovar eltor str. N16961 chromosome II, completehypothetical protein3e-0960.5
NC_011296:281930:283602283602283868267Thermodesulfovibrio yellowstonii DSM 11347, complete genomePZ12b6e-0959.3
NC_015850:2048251:211943021194302119585156Acidithiobacillus caldus SM-1 chromosome, complete genomeaddiction module antitoxin1e-0858.9
NC_013216:426877:430949430949431197249Desulfotomaculum acetoxidans DSM 771, complete genome1e-0858.9
NC_012560:1677798:169177216917721692050279Azotobacter vinelandii DJ, complete genomeplasmid stabilization system protein/addiction module toxin1e-0858.5
NC_021150:1677811:169178516917851692063279Azotobacter vinelandii CA6, complete genomeplasmid stabilization system protein/addiction module toxin1e-0858.5
NC_012846:986877:988774988774989034261Bartonella grahamii as4aup, complete genome2e-0857.8
NC_015519:2526047:252604725260472526322276Tepidanaerobacter sp. Re1 chromosome, complete genomeRelE/StbE family addiction module toxin1e-0755.1
NC_014355:399938:410359410359410628270Candidatus Nitrospira defluvii, complete genomerelE toxin2e-0754.7
NC_015437:27325:733147331473592279Selenomonas sputigena ATCC 35185 chromosome, complete genomeaddiction module toxin, RelE/StbE family2e-0754.7
NC_012846:1708840:172516417251641725415252Bartonella grahamii as4aup, complete genome1e-0652
NC_014355:399938:406481406481406750270Candidatus Nitrospira defluvii, complete genomerelE toxin6e-0649.7