Pre_GI: BLASTP Hits

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Query: NC_017379:1035464:1042610 Helicobacter pylori Puno135 chromosome, complete genome

Start: 1042610, End: 1042924, Length: 315

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017358:220900:244881244881245195315Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein2e-54211
NC_010698:870312:896499896499896813315Helicobacter pylori Shi470, complete genomehypothetical protein1e-52204
NC_017367:278916:301386301386301700315Helicobacter pylori F57, complete genomehypothetical protein2e-52204
NC_017376:57500:832278322783541315Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein2e-52203
NC_017361:930280:956537956537956851315Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein3e-52202
NC_014555:1526775:155454015545401554854315Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein5e-52202
NC_011333:1040192:106274010627401063054315Helicobacter pylori G27 chromosome, complete genomehypothetical protein7e-51198
NC_011498:448000:475253475253475567315Helicobacter pylori P12, complete genomehypothetical protein1e-50197
NC_017371:1030148:104594810459481046262315Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein2e-49194