Pre_GI: BLASTN Hits

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Query: NC_017378:986611 Helicobacter pylori Puno120 chromosome, complete genome

Start: 986611, End: 1004599, Length: 17989

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_008229:11494801149480117353024051Helicobacter acinonychis str. Sheeba, complete genome1e-84321BLASTN svgBLASTP svg
NC_000915:45395845395847406620109Helicobacter pylori 26695, complete genome04105BLASTN svgBLASTP svg
NC_000915:1044000*1044000106687422875Helicobacter pylori 26695, complete genome01532BLASTN svgBLASTP svg
NC_000921:10075191007519105809950581Helicobacter pylori J99, complete genome01019BLASTN svgBLASTP svg