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Query: NC_017376:57500:88651 Helicobacter pylori SNT49 chromosome, complete genome

Start: 88651, End: 88944, Length: 294

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011498:448000:480624480624480917294Helicobacter pylori P12, complete genomehypothetical protein2e-40163
NC_014256:448710:464079464079464372294Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-39161
NC_014555:1526775:154892215489221549215294Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein1e-39161
NC_011333:1040192:105739310573931057689297Helicobacter pylori G27 chromosome, complete genomehypothetical protein1e-39161
NC_017367:278916:296024296024296290267Helicobacter pylori F57, complete genomehypothetical protein2e-39160
NC_017379:1035464:104799010479901048283294Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein2e-38157
NC_017371:1030148:104059610405961040892297Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein5e-38155
NC_017358:220900:239521239521239814294Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein5e-38155
NC_017381:982216:994162994162994458297Helicobacter pylori 2018 chromosome, complete genomehypothetical protein2e-37154
NC_017374:974279:986207986207986503297Helicobacter pylori 2017 chromosome, complete genomehypothetical protein2e-37154
NC_017357:973392:985320985320985616297Helicobacter pylori 908 chromosome, complete genomehypothetical protein2e-37154
NC_017361:1528239:154119315411931541486294Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein4e-37153
NC_017361:930280:961795961795962091297Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein1e-36151
NC_010698:870312:902009902009902173165Helicobacter pylori Shi470, complete genomehypothetical protein3e-1373.6