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Query: NC_017376:57500:88093 Helicobacter pylori SNT49 chromosome, complete genome

Start: 88093, End: 88398, Length: 306

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011333:1040192:105793910579391058205267Helicobacter pylori G27 chromosome, complete genomehypothetical protein3e-1477.4
NC_011498:448000:480072480072480371300Helicobacter pylori P12, complete genomehypothetical protein3e-1477
NC_017357:973392:985866985866986165300Helicobacter pylori 908 chromosome, complete genomehypothetical protein4e-1476.6
NC_017381:982216:994708994708995007300Helicobacter pylori 2018 chromosome, complete genomehypothetical protein4e-1476.6
NC_017374:974279:986753986753987052300Helicobacter pylori 2017 chromosome, complete genomehypothetical protein4e-1476.6
NC_017361:930280:961246961246961545300Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein4e-1476.6
NC_014555:1526775:154946815494681549767300Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein1e-1375.1
NC_017371:1030148:104114210411421041441300Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein2e-1374.3
NC_017379:1035464:104743810474381047737300Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein5e-1373.2
NC_010698:870312:901328901328901627300Helicobacter pylori Shi470, complete genomehypothetical protein5e-1373.2
NC_014256:448710:464625464625464924300Helicobacter pylori B8 chromosome, complete genomehypothetical protein6e-1372.8
NC_017358:220900:240067240067240333267Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein2e-1271.2