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Query: NC_017376:57500:86423 Helicobacter pylori SNT49 chromosome, complete genome

Start: 86423, End: 86713, Length: 291

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1030148:104283110428311043121291Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein3e-31133
NC_014555:1526775:155115715511571551447291Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein3e-31133
NC_011498:448000:478392478392478682291Helicobacter pylori P12, complete genomehypothetical protein3e-31133
NC_014256:448710:466314466314466604291Helicobacter pylori B8 chromosome, complete genomehypothetical protein4e-31133
NC_017357:973392:987554987554987844291Helicobacter pylori 908 chromosome, complete genomehypothetical protein9e-31132
NC_017374:974279:988441988441988731291Helicobacter pylori 2017 chromosome, complete genomehypothetical protein9e-31132
NC_017381:982216:996396996396996686291Helicobacter pylori 2018 chromosome, complete genomehypothetical protein9e-31132
NC_017361:930280:959566959566959856291Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein3e-30130
NC_011333:1040192:105962710596271059917291Helicobacter pylori G27 chromosome, complete genomehypothetical protein3e-25114
NC_010698:870312:899648899648899938291Helicobacter pylori Shi470, complete genomehypothetical protein3e-24110
NC_017358:220900:241756241756242046291Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein4e-24109
NC_017379:1035464:104575910457591046049291Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein2e-23107
NC_017367:278916:298231298231298521291Helicobacter pylori F57, complete genomehypothetical protein5e-23106