Pre_GI: BLASTP Hits

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Query: NC_017376:57500:79809 Helicobacter pylori SNT49 chromosome, complete genome

Start: 79809, End: 80996, Length: 1188

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018939:1044000:1063774106377410649581185Helicobacter pylori 26695 chromosome, complete genomehypothetical protein0723
NC_000915:1044000:1063756106375610649401185Helicobacter pylori 26695, complete genomehypothetical protein0723
NC_014256:448710:4692224692224704061185Helicobacter pylori B8 chromosome, complete genomehypothetical protein0712
NC_010698:870312:8930958930958942731179Helicobacter pylori Shi470, complete genomehypothetical protein0704
NC_011498:448000:4718394718394730171179Helicobacter pylori P12, complete genomehypothetical protein0703
NC_017358:220900:2474082474082485921185Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein0701
NC_011333:1040192:1065271106527110664431173Helicobacter pylori G27 chromosome, complete genomehypothetical protein0695
NC_014555:1526775:1557084155708415582561173Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein0694
NC_017361:930280:9530209530209541921173Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein0689
NC_017371:1030148:1048593104859310497711179Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein0687
NC_017367:278916:3039313039313050941164Helicobacter pylori F57, complete genomehypothetical protein0685
NC_017375:1498000:1502519150251915036851167Helicobacter pylori 83 chromosome, complete genomehypothetical protein2e-81303