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Query: NC_017376:57500:59656 Helicobacter pylori SNT49 chromosome, complete genome

Start: 59656, End: 60987, Length: 1332

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018939:53715:6731067310688001491Helicobacter pylori 26695 chromosome, complete genomehypothetical protein0660
NC_000915:53715:6731067310688001491Helicobacter pylori 26695, complete genomehypothetical protein0660
NC_014555:47372:5929959299607651467Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein1e-150533
NC_012973:49208:6139061390630991710Helicobacter pylori B38 chromosome, complete genomehypothetical protein6e-105381
NC_017375:77142:783587835879110753Helicobacter pylori 83 chromosome, complete genomehypothetical protein3e-62239
NC_017375:77142:779977799778383387Helicobacter pylori 83 chromosome, complete genomehypothetical protein1e-1068.2