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Query: NC_017376:57500:59314 Helicobacter pylori SNT49 chromosome, complete genome

Start: 59314, End: 59574, Length: 261

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012973:49208:611196111961379261Helicobacter pylori B38 chromosome, complete genomehypothetical protein9e-41165
NC_014560:53750:675066750667766261Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein3e-39160
NC_014555:47372:590285902859288261Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein2e-38157
NC_018939:53715:670396703967299261Helicobacter pylori 26695 chromosome, complete genomehypothetical protein6e-38155
NC_000915:53715:670396703967299261Helicobacter pylori 26695, complete genomehypothetical protein6e-38155
NC_017375:77142:777277772777855129Helicobacter pylori 83 chromosome, complete genomehypothetical protein5e-1579.7
NC_010002:4572573:460143646014364601705270Delftia acidovorans SPH-1, complete genomehypothetical protein3e-0650.8
NC_010170:4463000:449303144930314493300270Bordetella petrii, complete genomehypothetical protein8e-0649.3
NC_010170:4409683:442361844236184423887270Bordetella petrii, complete genomehypothetical protein8e-0649.3