Pre_GI: BLASTP Hits

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Query: NC_017376:57500:58912 Helicobacter pylori SNT49 chromosome, complete genome

Start: 58912, End: 59298, Length: 387

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018939:53715:664546645467023570Helicobacter pylori 26695 chromosome, complete genomehypothetical protein2e-61233
NC_000915:53715:664546645467023570Helicobacter pylori 26695, complete genomehypothetical protein2e-61233
NC_017375:77142:771427714277711570Helicobacter pylori 83 chromosome, complete genomehypothetical protein8e-58221
NC_012973:49208:605346053461103570Helicobacter pylori B38 chromosome, complete genomehypothetical protein1e-56217
NC_014555:47372:584435844359012570Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein2e-54210
NC_014560:53750:669216692167490570Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein1e-56218