Pre_GI: BLASTP Hits

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Query: NC_017376:538000:538913 Helicobacter pylori SNT49 chromosome, complete genome

Start: 538913, End: 539260, Length: 348

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017354:848500:867273867273867716444Helicobacter pylori 52 chromosome, complete genomecag pathogenicity island protein (cag1)1e-39161
NC_017372:855384:873902873902874249348Helicobacter pylori India7 chromosome, complete genomecag pathogenicity island protein (cag1)2e-39160
NC_017360:1052473:107124410712441071591348Helicobacter pylori 35A chromosome, complete genomecag pathogenicity island protein1e-38157
NC_014560:518582:537308537308537655348Helicobacter pylori SJM180 chromosome, complete genomecag pathogenicity island protein (cag1)1e-38157
NC_017375:872478:890942890942891289348Helicobacter pylori 83 chromosome, complete genomecag pathogenicity island protein2e-38157
NC_017359:813500:831721831721832068348Helicobacter pylori Sat464 chromosome, complete genomecag pathogenicity island protein (cag zeta, cag1)4e-38156
NC_017355:493237:493237493237493584348Helicobacter pylori v225d chromosome, complete genomeCag14e-38156
NC_017365:848500:867527867527867874348Helicobacter pylori F30, complete genomecag pathogenicity island protein7e-38155
NC_014256:683384:702739702739703086348Helicobacter pylori B8 chromosome, complete genomecag pathogenicity island protein zeta7e-38155
NC_017357:495213:498315498315498662348Helicobacter pylori 908 chromosome, complete genomecag pathogenicity island protein7e-38155
NC_017368:852490:870948870948871295348Helicobacter pylori F16, complete genomecag pathogenicity island protein2e-37154