Pre_GI: BLASTP Hits

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Query: NC_017375:77142:95071 Helicobacter pylori 83 chromosome, complete genome

Start: 95071, End: 95715, Length: 645

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017063:834674:849002849002849973972Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein2e-89328
NC_017372:748097:785877785877786854978Helicobacter pylori India7 chromosome, complete genomehypothetical protein3e-104377
NC_017371:1470582:150899315089931509955963Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein1e-73275
NC_011498:1391788:140606814060681407030963Helicobacter pylori P12, complete genomehypothetical protein5e-75280
NC_014256:485969:514715514715515677963Helicobacter pylori B8 chromosome, complete genomehypothetical protein2e-81301