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Query: NC_017375:77142:93009 Helicobacter pylori 83 chromosome, complete genome

Start: 93009, End: 93227, Length: 219

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017366:1055319:1067305106730510693682064Helicobacter pylori F32, complete genometopoisomerase I5e-1993.2
NC_017379:1035464:1035464103546410375242061Helicobacter pylori Puno135 chromosome, complete genometopoisomerase I8e-1889
NC_017378:1518529:1532480153248015345432064Helicobacter pylori Puno120 chromosome, complete genometopoisomerase I3e-1787
NC_017372:748097:7710867710867731492064Helicobacter pylori India7 chromosome, complete genometopoisomerase I2e-1684.3
NC_017362:1512959:1539110153911015411702061Helicobacter pylori Lithuania75 chromosome, complete genomeDNA topoisomerase I6e-1579.7
NC_017063:834674:8635798635798656392061Helicobacter pylori ELS37 chromosome, complete genometopoisomerase I6e-1579.3
NC_017371:1470582:1493285149328514953452061Helicobacter pylori Gambia94/24 chromosome, complete genomeDNA topoisomerase I6e-1579.3
NC_014256:485969:5087525087525108122061Helicobacter pylori B8 chromosome, complete genomeDNA topoisomerase I6e-1579.3
NC_000921:1007519:1032846103284610349062061Helicobacter pylori J99, complete genometopoisomerase I2e-1477.8
NC_014560:1366747:1390880139088013929402061Helicobacter pylori SJM180 chromosome, complete genometopoisomerase I2e-1477.4