Pre_GI: BLASTP Hits

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Query: NC_017375:77142:83716 Helicobacter pylori 83 chromosome, complete genome

Start: 83716, End: 84966, Length: 1251

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017372:748097:7616027616027628371236Helicobacter pylori India7 chromosome, complete genomehypothetical protein2e-97356
NC_014560:1366747:1401261140126114025291269Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein9e-173606
NC_000921:1007519:1038613103861310398781266Helicobacter pylori J99, complete genomehypothetical protein3e-174611
NC_017378:1518529:1542589154258915438541266Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein8e-176616
NC_017362:1512959:1525558152555815268201263Helicobacter pylori Lithuania75 chromosome, complete genometype IV secretion system protein TrbL3e-169594
NC_014256:485969:4990684990685003241257Helicobacter pylori B8 chromosome, complete genometype IV secretion system protein TrbL3e-164578
NC_017063:834674:8737508737508750121263Helicobacter pylori ELS37 chromosome, complete genometype IV secretion system protein TrbL2e-167589
NC_017371:1470582:1483577148357714848391263Helicobacter pylori Gambia94/24 chromosome, complete genometype IV secretion system protein TrbL9e-168590