Pre_GI: BLASTP Hits

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Query: NC_017375:1498000:1516042 Helicobacter pylori 83 chromosome, complete genome

Start: 1516042, End: 1517544, Length: 1503

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1470582:1509968150996815122082241Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein7e-52205
NC_017367:278916:3174963174963196132118Helicobacter pylori F57, complete genomehypothetical protein2e-112406
NC_017371:1030148:1062302106230210644732172Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein7e-111401
NC_017372:748097:7868677868677891282262Helicobacter pylori India7 chromosome, complete genomehypothetical protein6e-52205
NC_011498:1391788:1403813140381314055971785Helicobacter pylori P12, complete genomehypothetical protein2e-51204
NC_010698:870312:8787308787308808712142Helicobacter pylori Shi470, complete genomehypothetical protein2e-112406
NC_017361:1528239:1561161156116115633562196Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein2e-111403
NC_011498:448000:4577914577914592721482Helicobacter pylori P12, complete genomehypothetical protein1e-87324
NC_017375:77142:9572895728975721845Helicobacter pylori 83 chromosome, complete genomehypothetical protein1e-51204
NC_000921:1007519:1049874104987410518802007Helicobacter pylori J99, complete genomehypothetical protein5e-113408
NC_017361:930280:9385279385279407222196Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein2e-111403
NC_017358:220900:2603022603022624942193Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein1e-104380
NC_014256:485969:5156905156905179302241Helicobacter pylori B8 chromosome, complete genomehypothetical protein7e-52205
NC_014560:1366747:1377248137724813794582211Helicobacter pylori SJM180 chromosome, complete genomeperiplasmic competence protein-like protein1e-111404
NC_011333:1040192:1078838107883810810512214Helicobacter pylori G27 chromosome, complete genomeperiplasmic competence protein-like protein2e-110399