Pre_GI: BLASTP Hits

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Query: NC_017372:902043:909486 Helicobacter pylori India7 chromosome, complete genome

Start: 909486, End: 911330, Length: 1845

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014256:636000:6431486431486449921845Helicobacter pylori B8 chromosome, complete genomehypothetical protein01109
NC_014762:890914:9083849083849101951812Sulfuricurvum kujiense DSM 16994 chromosome, complete genomehypothetical protein2e-0964.7
NC_015318:249445:2622332622332640231791Hippea maritima DSM 10411 chromosome, complete genomehypothetical protein4e-0757