Pre_GI: BLASTP Hits

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Query: NC_017372:902043:908309 Helicobacter pylori India7 chromosome, complete genome

Start: 908309, End: 908737, Length: 429

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014256:636000:645872645872646768897Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-56218
NC_000921:1147394:1157436115743611609003465Helicobacter pylori J99, complete genomehypothetical protein8e-56215
NC_017372:902043:9049579049579083343378Helicobacter pylori India7 chromosome, complete genomehypothetical protein7e-50195
NC_017372:1212000:1226126122612612319815856Helicobacter pylori India7 chromosome, complete genomehypothetical protein1e-21101
NC_009715:1829978:1846407184640718495533147Campylobacter curvus 525.92 chromosome, complete genomehypothetical protein2e-1064.7