Pre_GI: BLASTP Hits

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Query: NC_017372:902043:902978 Helicobacter pylori India7 chromosome, complete genome

Start: 902978, End: 903166, Length: 189

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010698:870312:872440872440872628189Helicobacter pylori Shi470, complete genome50S ribosomal protein L286e-2096.3
NC_014256:636000:651504651504651692189Helicobacter pylori B8 chromosome, complete genome50S ribosomal protein L284e-1993.2
NC_007575:1663088:168295816829581683146189Sulfurimonas denitrificans DSM 1251, complete genome50S ribosomal protein L283e-1063.9
NC_014166:2217790:223196122319612232149189Arcobacter nitrofigilis DSM 7299 chromosome, complete genome50S ribosomal protein L285e-1063.2