Pre_GI: BLASTP Hits

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Query: NC_017362:1512959:1537073 Helicobacter pylori Lithuania75 chromosome, complete genome

Start: 1537073, End: 1537720, Length: 648

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000921:1007519:1036277103627710372961020Helicobacter pylori J99, complete genomehypothetical protein3e-107387
NC_017063:834674:867011867011867676666Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein3e-107387
NC_014256:485969:506715506715507380666Helicobacter pylori B8 chromosome, complete genomehypothetical protein9e-107385
NC_011498:1391788:141448014144801415145666Helicobacter pylori P12, complete genomehypothetical protein3e-106384
NC_017371:1470582:149124814912481491913666Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein7e-106382
NC_014560:1366747:139431213943121394977666Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein7e-101366
NC_017378:1518529:153593115359311536569639Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein7e-90329
NC_017366:1055319:107078610707861071358573Helicobacter pylori F32, complete genomehypothetical protein1e-69262
NC_017375:77142:910209102091592573Helicobacter pylori 83 chromosome, complete genomehypothetical protein6e-69260
NC_017372:748097:769114769114769677564Helicobacter pylori India7 chromosome, complete genomehypothetical protein8e-68256