Pre_GI: BLASTP Hits

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Query: NC_017362:1512959:1536718 Helicobacter pylori Lithuania75 chromosome, complete genome

Start: 1536718, End: 1537095, Length: 378

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1470582:149089314908931491270378Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein2e-41167
NC_017063:834674:867654867654868031378Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein2e-41167
NC_000921:1007519:1036277103627710372961020Helicobacter pylori J99, complete genomehypothetical protein3e-41166
NC_014256:485969:506360506360506737378Helicobacter pylori B8 chromosome, complete genomehypothetical protein5e-41166
NC_017378:1518529:153654715365471536939393Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein3e-34143
NC_014560:1366747:139495513949551395347393Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein2e-33140
NC_017372:748097:768750768750769127378Helicobacter pylori India7 chromosome, complete genomehypothetical protein3e-32137
NC_017375:77142:906059060591042438Helicobacter pylori 83 chromosome, complete genomehypothetical protein6e-31132
NC_017366:1055319:107133610713361071695360Helicobacter pylori F32, complete genomehypothetical protein3e-29127
NC_011498:1391788:141512314151231415401279Helicobacter pylori P12, complete genomehypothetical protein5e-22102