Pre_GI: BLASTP Hits

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Query: NC_017362:1512959:1522039 Helicobacter pylori Lithuania75 chromosome, complete genome

Start: 1522039, End: 1522842, Length: 804

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018939:1044000:105505510550551055858804Helicobacter pylori 26695 chromosome, complete genomehypothetical protein3e-153541
NC_017063:834674:878553878553879356804Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein3e-153541
NC_014256:485969:494711494711495514804Helicobacter pylori B8 chromosome, complete genomehypothetical protein3e-153541
NC_000915:1044000:105503810550381055841804Helicobacter pylori 26695, complete genomehypothetical protein5e-153540
NC_017371:1470582:147922614792261480029804Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein6e-150530
NC_017372:748097:757510757510758334825Helicobacter pylori India7 chromosome, complete genomehypothetical protein2e-124445
NC_015942:355944:375988375988376677690Acidithiobacillus ferrivorans SS3 chromosome, complete genomehypothetical protein5e-1065.1
NC_015422:910292:918594918594919250657Alicycliphilus denitrificans K601 chromosome, complete genomehypothetical protein7e-0961.2
NC_009468:38112:570235702357577555Acidiphilium cryptum JF-5 plasmid pACRY02, complete sequencehypothetical protein4e-0858.9
NC_000921:1007519:104239010423901043367978Helicobacter pylori J99, complete genomehypothetical protein6e-0651.6