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Query: NC_017358:182854 Helicobacter pylori Cuz20 chromosome, complete genome

Start: 182854, End: 218827, Length: 35974

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_000921:11473941147394117046423071Helicobacter pylori J99, complete genome01158BLASTN svgBLASTP svg
NC_008229:13973611397361142029022930Helicobacter acinonychis str. Sheeba, complete genome2e-159571BLASTN svgBLASTP svg
NC_010698:870312*87031291055740246Helicobacter pylori Shi470, complete genome4e-120440BLASTN svgBLASTP svg
NC_009662:383381*38338140149218112Nitratiruptor sp. SB155-2, complete genome7e-1177.8BLASTN svgBLASTP svg
NC_013161:18787001878700190383825139Cyanothece sp. PCC 8802, complete genome4e-0661.9BLASTN svgBLASTP svg
NC_011726:19115001911500193401122512Cyanothece sp. PCC 8801, complete genome4e-0661.9BLASTN svgBLASTP svg