Pre_GI: BLASTP Hits

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Query: NC_017357:495213:508565 Helicobacter pylori 908 chromosome, complete genome

Start: 508565, End: 508897, Length: 333

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017374:498588:5066765066765080761401Helicobacter pylori 2017 chromosome, complete genomecag pathogenicity island protein3e-23107
NC_000921:511642:5180745180745235335460Helicobacter pylori J99, complete genomecag island protein5e-23106
NC_017063:800156:8070168070168125865571Helicobacter pylori ELS37 chromosome, complete genomecag pathogenicity island protein (cag7)2e-21100
NC_017371:530673:5371025371025429185817Helicobacter pylori Gambia94/24 chromosome, complete genomecag pathogenicity island protein Y VirB10-like protein2e-21100
NC_011498:553525:5599645599645656695706Helicobacter pylori P12, complete genomecag pathogenicity island protein Y VirB10-like protein1e-2098.2
NC_014560:518582:5253015253015307815481Helicobacter pylori SJM180 chromosome, complete genomecag island protein5e-2096.3
NC_017362:506950:5132665132665190315766Helicobacter pylori Lithuania75 chromosome, complete genomecag pathogenicity island protein (cag7, cagY)2e-1994.4
NC_008086:513407:5241735241735261611989Helicobacter pylori HPAG1, complete genomecag pathogenicity island protein Y5e-1993.2
NC_018939:547793:5542165542165599995784Helicobacter pylori 26695 chromosome, complete genomecag pathogenicity island protein (cag7)1e-1891.7
NC_000915:547783:5542065542065599895784Helicobacter pylori 26695, complete genomecag pathogenicity island protein (cag7)1e-1891.7
NC_017381:500699:509590509590509976387Helicobacter pylori 2018 chromosome, complete genomecag pathogenicity island protein1e-1891.7
NC_017372:855384:8620738620738673525280Helicobacter pylori India7 chromosome, complete genomecag pathogenicity island protein (cag7)2e-1890.9
NC_017375:872478:8790618790618809471887Helicobacter pylori 83 chromosome, complete genomehypothetical protein2e-1890.9
NC_014256:683384:6900696900696955345466Helicobacter pylori B8 chromosome, complete genomecag pathogenicity island protein Y3e-1890.5
NC_017376:538000:5458135458135512065394Helicobacter pylori SNT49 chromosome, complete genomecag pathogenicity island protein (cag7)6e-1889.4
NC_017365:848500:8552608552608610405781Helicobacter pylori F30, complete genomecag pathogenicity island protein1e-1788.2
NC_017366:535188:5414455414455474536009Helicobacter pylori F32, complete genomecag pathogenicity island protein Y VirB10-like protein2e-1787.8
NC_017354:848500:8552788552788609745697Helicobacter pylori 52 chromosome, complete genomeconjugation TrbI family protein4e-1786.7
NC_017360:1052473:1059362105936210647555394Helicobacter pylori 35A chromosome, complete genomecag pathogenicity island protein8e-1785.9
NC_017368:852490:8590688590688644585391Helicobacter pylori F16, complete genomecag island protein7e-1785.9
NC_017367:562918:5691785691785745715394Helicobacter pylori F57, complete genomecag pathogenicity island protein Y VirB10-like protein7e-1785.9
NC_017355:493237:4998824998825051885307Helicobacter pylori v225d chromosome, complete genomecag pathogenicity island protein1e-1685.1
NC_010698:819912:8326658326658382295565Helicobacter pylori Shi470, complete genomecag pathogenicity island protein (cag7)8e-1682.4
NC_017379:505350:5117665117665173695604Helicobacter pylori Puno135 chromosome, complete genomecag pathogenicity island protein2e-1581.3
NC_017359:813500:8202648202648254235160Helicobacter pylori Sat464 chromosome, complete genomecag pathogenicity island protein (cagY, cag7)2e-1581.3
NC_017378:502806:5088765088765145515676Helicobacter pylori Puno120 chromosome, complete genomecag pathogenicity island protein (cag7)2e-1581.3