Pre_GI: BLASTP Hits

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Query: NC_017354:1465925:1483539 Helicobacter pylori 52 chromosome, complete genome

Start: 1483539, End: 1483614, Length: 76

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017378:1489818:15116391511639151171476Helicobacter pylori Puno120 chromosome, complete genometRNA-Phe1e-0651.6
NC_017371:1601452:16234861623486162356176Helicobacter pylori Gambia94/24 chromosome, complete genometRNA-Phe1e-0651.6
NC_017367:1505780:15261571526157152623276Helicobacter pylori F57, complete genometRNA-Phe1e-0651.6
NC_017365:1466500:14872271487227148730276Helicobacter pylori F30, complete genometRNA-Phe1e-0651.6
NC_014555:1477934:14955521495552149562776Helicobacter pylori PeCan4 chromosome, complete genometRNA-Phe1e-0651.6