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Query: NC_017354:1465925:1477680 Helicobacter pylori 52 chromosome, complete genome

Start: 1477680, End: 1478288, Length: 609

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017367:1505780:152041715204171521031615Helicobacter pylori F57, complete genomeType III DNA modification enzyme3e-109394
NC_017378:1489818:150593915059391506520582Helicobacter pylori Puno120 chromosome, complete genometype III DNA modification enzyme (methyltransferase)2e-102371
NC_017365:1466500:148143614814361482017582Helicobacter pylori F30, complete genomeType III DNA modification enzyme5e-102369
NC_014555:1477934:148979814897981490379582Helicobacter pylori PeCan4 chromosome, complete genometype III DNA modification enzyme (methyltransferase)6e-100362
NC_011498:1571840:1585069158506915871112043Helicobacter pylori P12, complete genometype III R-M system methyltransferase1e-99362
NC_017371:1601452:161769216176921618279588Helicobacter pylori Gambia94/24 chromosome, complete genometype III R-M system modification enzyme9e-99358
NC_018939:1583653:160012516001251600712588Helicobacter pylori 26695 chromosome, complete genometype III R-M system modification enzyme2e-98357
NC_016751:142237:1594331594331615772145Marinitoga piezophila KA3 chromosome, complete genomeadenine specific DNA methylase Mod1e-1066.2
NC_017372:748097:7480977480977499651869Helicobacter pylori India7 chromosome, complete genomeadenine specific DNA methyltransferase2e-1065.9
NC_015381:4363005:437836143783614379278918Burkholderia gladioli BSR3 chromosome 1, complete sequence9e-0960.1
NC_010170:4463000:4487301448730144891991899Bordetella petrii, complete genometype III restriction system methylase2e-0755.8
NC_012724:1:1648616486185102025Burkholderia glumae BGR1 chromosome 1, complete genomehypothetical protein2e-0755.5
NC_013124:1439915:1452724145272414546791956Acidimicrobium ferrooxidans DSM 10331, complete genomeDNA methylase N-4/N-6 domain protein3e-0755.5
NC_014206:2266000:2271726227172622736271902Geobacillus sp. C56-T3 chromosome, complete genomeadenine-specific DNA-methyltransferase3e-0755.1
NC_010002:4572573:4605537460553746075221986Delftia acidovorans SPH-1, complete genomeDNA methylase N-4/N-6 domain protein5e-0754.3
NC_020387:149890:1643621643621662841923Dehalococcoides mccartyi BTF08, complete genometype III restriction-modification protein, methylation subunit9e-0753.5