Pre_GI: BLASTP Hits

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Query: NC_017328:303987:325599 Shigella flexneri 2002017 chromosome, complete genome

Start: 325599, End: 326075, Length: 477

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009800:289000:309479309479309955477Escherichia coli HS, complete genomephage lysozyme1e-89328
NC_012947:3015985:301644330164433016919477Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeLysozyme4e-89326
NC_006905:368942:391670391670392146477Salmonella enterica subsp. enterica serovar Choleraesuis strlysin6e-89325
NC_012125:1330066:135294813529481353421474Salmonella enterica subsp. enterica serovar Paratyphi C strainlysin9e-89325
NC_003198:1908238:191258519125851913061477Salmonella enterica subsp. enterica serovar Typhi str. CT18,putative endolysin1e-81301
NC_013941:3182576:318534331853433185819477Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeLysozyme4e-80296
NC_020063:2565605:257210025721002572576477Enterobacteriaceae bacterium strain FGI 57, complete genomemuramidase (phage lambda lysozyme)3e-78290
NC_011283:2836000:289756728975672898046480Klebsiella pneumoniae 342 chromosome, complete genomephage lysozyme2e-70264
NC_009648:3803622:381947238194723819969498Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeputative prophage endolysin, control of lysis2e-38157
NC_012912:1701231:174462217446221745113492Dickeya zeae Ech1591, complete genomeLysozyme9e-38155
NC_014500:3097362:310176631017663102254489Dickeya dadantii 3937 chromosome, complete genomeLysozyme2e-37154
NC_013592:1668092:168477516847751685266492Dickeya dadantii Ech586, complete genomeLysozyme7e-37152
NC_017986:4931104:494128749412874941826540Pseudomonas putida ND6 chromosome, complete genomeendolysin3e-36150
NC_012880:2480000:249635024963502496841492Dickeya dadantii Ech703, complete genomeLysozyme2e-35147
NC_008390:2018201:203513820351382035590453Burkholderia cepacia AMMD chromosome 1, complete sequenceglycoside hydrolase, family 245e-34143
NC_002947:4362271:437817143781714378710540Pseudomonas putida KT2440, complete genomeendolysin9e-34142
NC_015733:1398083:140619214061921406692501Pseudomonas putida S16 chromosome, complete genomeendolysin1e-31135
NC_008314:1465643:146609414660941466729636Ralstonia eutropha H16 chromosome 2, complete sequenceMuramidase (phage lysozyme)9e-28122
NC_014500:2019113:2037269203726920389631695Dickeya dadantii 3937 chromosome, complete genomeLysozyme9e-2199
NC_013592:2703327:2710622271062227123161695Dickeya dadantii Ech586, complete genomeglycoside hydrolase family 242e-2097.8
NC_015137:2582467:258418625841862584836651Burkholderia sp. CCGE1001 chromosome 2, complete sequenceglycoside hydrolase family 245e-2096.7
NC_009481:764382:765098765098765721624Synechococcus sp. WH 7803 chromosome, complete genomemuramidase8e-1785.9
NC_007513:987969:101201210120121012686675Synechococcus sp. CC9902, complete genomepossible muramidase, COG46786e-1476.6
NC_011000:2732330:273984227398422740369528Burkholderia cenocepacia J2315 chromosome 1, complete sequenceputative lysozyme1e-1375.1
NC_008820:1356858:136004013600401360840801Prochlorococcus marinus str. MIT 9303, complete genomepossible endolysin2e-1374.3
NC_005071:704882:720843720843721619777Prochlorococcus marinus str. MIT 9313, complete genomepossible endolysin2e-1374.3
NC_008319:1306482:130971713097171310460744Synechococcus sp. CC9311, complete genomepossible endolysin2e-1271.6
NC_014733:1223359:124555012455501246419870Methylovorus sp. MP688 chromosome, complete genomepaar repeat-containing protein7e-1063.2
NC_011035:829945:865739865739865996258Neisseria gonorrhoeae NCCP11945 chromosome, complete genomeAtlA protein3e-0650.8
NC_014307:1271121:127471412747141274968255Ralstonia solanacearum CFBP2957 chromosome, complete genomehypothetical protein9e-0649.3