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Query: NC_017328:303987:325292 Shigella flexneri 2002017 chromosome, complete genome

Start: 325292, End: 325615, Length: 324

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009800:289000:309172309172309495324Escherichia coli HS, complete genomephage holin, lambda family7e-56215
NC_006905:368942:391363391363391686324Salmonella enterica subsp. enterica serovar Choleraesuis strholin-like protein7e-56215
NC_012947:3015985:301690330169033017226324Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completephage holin, lambda family4e-55212
NC_012125:1330066:135264413526441352961318Salmonella enterica subsp. enterica serovar Paratyphi C strainholin-like protein1e-54211
NC_006511:2501500:250893825089382509264327Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCClysis (holin)3e-49193
NC_011147:2496808:250447425044742504800327Salmonella enterica subsp. enterica serovar Paratyphi A strholin3e-49193
NC_011205:609464:634928634928635254327Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853phage holin, lambda family3e-49193
NC_010067:2529750:258053225805322580855324Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein1e-48191
NC_011283:2836000:289803028980302898353324Klebsiella pneumoniae 342 chromosome, complete genomephage holin, lambda family1e-44178
NC_013892:3803278:382638538263853826711327Xenorhabdus bovienii SS-2004 chromosome, complete genomeHolin (Lysis protein 13)2e-25114
NC_012214:1974500:198806919880691988404336Erwinia pyrifoliae Ep1/96, complete genomeSimilar to phage lysis protein S3e-1167
NC_011770:860944:881354881354881686333Pseudomonas aeruginosa LESB58, complete genomeHolin, phage lambda5e-0753.1
NC_011770:1431740:145172214517221452111390Pseudomonas aeruginosa LESB58, complete genomehypothetical protein2e-0651.6