Pre_GI: BLASTP Hits

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Query: NC_017328:303987:318738 Shigella flexneri 2002017 chromosome, complete genome

Start: 318738, End: 319034, Length: 297

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011740:2072173:210936321093632109659297Escherichia fergusonii ATCC 35469, complete genomeRegulatory protein CII from phage origin2e-51201
NC_011601:1039500:105289810528981053194297Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomeregulatory protein7e-51198
NC_011353:3276734:328109632810963281392297Escherichia coli O157:H7 str. EC4115 chromosome, complete genomebacteriophage CII protein2e-50197
NC_013008:3231414:323596732359673236263297Escherichia coli O157:H7 str. TW14359 chromosome, complete genomeregulatory protein CII of bacteriophage BP-933W2e-50197
NC_008563:1175035:118879711887971189093297Escherichia coli APEC O1, complete genomeputative regulatory protein CII of bacteriophage2e-50197
NC_007946:1239278:125141012514101251706297Escherichia coli UTI89, complete genomeputative regulatory protein CII of bacteriophage2e-50197
NC_004431:1401681:141356214135621413858297Escherichia coli CFT073, complete genomePutative Regulatory protein CII of bacteriophage2e-50197
NC_011742:1177946:119238611923861192682297Escherichia coli S88 chromosome, complete genomeRegulatory protein CII from phage origin2e-50197
NC_011601:2614691:261888226188822619178297Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomeregulatory protein3e-48189
NC_011751:1405381:142031414203141420613300Escherichia coli UMN026 chromosome, complete genomeregulatory protein CII from phage origin3e-48189
NC_011601:717072:731767731767732066300Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomeregulatory protein4e-48189
NC_013941:975353:990356990356990655300Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeregulatory protein CII1e-47188
NC_012947:3015985:302095330209533021252300Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeCII family protein6e-46182
NC_013364:2645438:265155626515562651852297Escherichia coli O111:H- str. 11128, complete genomeputative phage regulatory protein CII6e-46182
NC_013361:1558423:157164615716461571942297Escherichia coli O26:H11 str. 11368 chromosome, complete genomephage regulatory protein CII2e-45181
NC_013364:1183000:119531211953121195608297Escherichia coli O111:H- str. 11128, complete genomeputative phage regulatory protein2e-44177
NC_013353:5361207:537804653780465378342297Escherichia coli O103:H2 str. 12009, complete genomephage regulatory protein CII2e-44177
NC_002655:1332961:134405513440551344351297Escherichia coli O157:H7 EDL933, complete genomeputative regulatory protein CII of bacteriophage BP-933W2e-44177
AP010958:5361207:537804653780465378342297Escherichia coli O103:H2 str. 12009 DNA, complete genomephage regulatory protein CII2e-44177
NC_013361:3112023:312917331291733129469297Escherichia coli O26:H11 str. 11368 chromosome, complete genomephage regulatory protein CII6e-43172
NC_013941:3300000:330197933019793302275297Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeCII protein6e-43172
NC_009800:289000:302472302472302768297Escherichia coli HS, complete genomebacteriophage CII protein9e-43171
NC_013282:1200993:121548112154811215762282Cronobacter turicensis, complete genomehypothetical protein9e-38155
NC_013008:306953:306953306953307246294Escherichia coli O157:H7 str. TW14359 chromosome, complete genomecII antiterminator protein for prophage CP-933H1e-0755.1
NC_002695:301939:303072303072303365294Escherichia coli O157:H7 str. Sakai, complete genomecII1e-0755.1
NC_002655:301940:303073303073303366294Escherichia coli O157:H7 EDL933, complete genomeputative cII antiterminator protein for prophage CP-933H1e-0755.1
NC_007946:2625461:262931726293172629610294Escherichia coli UTI89, complete genomebacteriophage 343 regulatory protein CII3e-0754.3