Pre_GI: BLASTP Hits

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Query: NC_017328:303987:314367 Shigella flexneri 2002017 chromosome, complete genome

Start: 314367, End: 314807, Length: 441

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008258:269806:282426282426282908483Shigella flexneri 5 str. 8401, complete genomehypothetical protein2e-74276
NC_013850:1887556:189631418963141896796483Klebsiella variicola At-22 chromosome, complete genomeGp157 family protein3e-59226
NC_009800:289000:296307296307296666360Escherichia coli HS, complete genomehypothetical protein2e-56217
NC_013282:1200993:120990712099071210389483Cronobacter turicensis, complete genomehypothetical protein3e-54210
NC_009800:289000:297848297848298021174Escherichia coli HS, complete genomehypothetical protein8e-1475.9
NC_012214:1974500:197793619779361978499564Erwinia pyrifoliae Ep1/96, complete genomehypothetical protein1e-1271.6
CP002797:4812799:482840048284004828969570Escherichia coli NA114, complete genomeHypothetical protein3e-1270.5
NC_011415:2277559:230675623067562307325570Escherichia coli SE11 chromosome, complete genomehypothetical protein7e-1269.3
NC_009801:2193000:221900422190042219573570Escherichia coli E24377A, complete genomehypothetical protein8e-1269.3
NC_009674:2985878:301573530157353016217483Bacillus cytotoxicus NVH 391-98 chromosome, complete genomesiphovirus Gp157 family protein3e-1167.4
NC_013171:896802:900680900680901147468Anaerococcus prevotii DSM 20548, complete genomeGp157 family protein3e-1167
NC_010610:535790:543201543201543686486Lactobacillus fermentum IFO 3956, complete genomehypothetical protein6e-1166.2
NC_014624:2944437:295948529594852959982498Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein1e-1065.1
NC_014624:1235818:123848212384821238994513Eubacterium limosum KIST612 chromosome, complete genomesiphovirus family protein1e-1065.1
NC_011837:3272752:328526032852603285748489Clostridium kluyveri NBRC 12016, complete genomehypothetical protein5e-1063.2
NC_009706:3341250:335375833537583354246489Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein5e-1063.2
NC_003212:2293425:231435323143532314829477Listeria innocua Clip11262, complete genomehypothetical protein7e-1062.8
NC_004116:560893:567249567249567731483Streptococcus agalactiae 2603V/R, complete genomehypothetical protein9e-1062.4
NC_012984:520000:521519521519521998480Lactobacillus plantarum JDM1, complete genomehypothetical protein9e-1062.4
NC_008024:804157:808633808633809115483Streptococcus pyogenes MGAS10750, complete genomephage protein1e-0962
NC_008022:771767:777366777366777848483Streptococcus pyogenes MGAS10270, complete genomephage protein1e-0962
NC_004606:877707:885614885614886096483Streptococcus pyogenes SSI-1, complete genomehypothetical protein1e-0961.6
NC_007297:1001981:101269210126921013174483Streptococcus pyogenes MGAS5005, complete genomephage protein2e-0960.8
NC_016052:1839763:185568418556841856166483Tetragenococcus halophilus NBRC 12172, complete genomehypothetical protein2e-0960.8
NC_004606:623853:632217632217632699483Streptococcus pyogenes SSI-1, complete genomehypothetical protein3e-0960.8
NC_008555:1204000:121776512177651218244480Listeria welshimeri serovar 6b str. SLCC5334, complete genomehypothetical protein4e-0960.1
NC_009495:2479465:251706025170602517545486Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein8e-0959.3
NC_014652:801653:803311803311803793483Caldicellulosiruptor hydrothermalis 108 chromosome, completegp157 family protein1e-0858.5
NC_011660:366000:366012366012366488477Listeria monocytogenes HCC23 chromosome, complete genomehypothetical protein1e-0858.5
NC_004129:4368356:438674843867484387281534Pseudomonas fluorescens Pf-5, complete genomehypothetical protein1e-0858.5
NC_012891:1573435:159773315977331598215483Streptococcus dysgalactiae subsp. equisimilis GGS_124 chromosome 1,phage protein3e-0857.4
NC_014722:846084:851927851927852433507Burkholderia rhizoxinica HKI 454, complete genomephage protein6e-0856.2
NC_009089:1093832:109776810977681098283516Clostridium difficile 630, complete genomephage protein1e-0755.5
NC_009641:1105075:110507511050751105554480Staphylococcus aureus subsp. aureus str. Newman chromosome,hypothetical protein2e-0754.7
NC_012563:2597934:260656626065662607051486Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-0753.9
NC_018012:598724:601604601604602104501Thiocystis violascens DSM 198 chromosome, complete genomesiphovirus Gp157 protein5e-0753.1
NC_020164:1677452:170934617093461709831486Staphylococcus warneri SG1, complete genomehypothetical protein5e-0753.1
NC_013223:1848689:186530018653001865791492Desulfohalobium retbaense DSM 5692, complete genomehypothetical protein2e-0651.6
NC_003210:2380419:239431723943172394793477Listeria monocytogenes EGD-e, complete genomehypothetical protein2e-0651.2
NC_013768:1260317:127021812702181270697480Listeria monocytogenes 08-5923, complete genomehypothetical protein4e-0650.1
NC_013766:1293144:130351413035141303993480Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein4e-0650.1
NC_013450:854790:862162862162862641480Staphylococcus aureus subsp. aureus ED98, complete genomehypothetical protein7e-0649.3