Pre_GI: BLASTP Hits

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Query: NC_017328:303987:313288 Shigella flexneri 2002017 chromosome, complete genome

Start: 313288, End: 313737, Length: 450

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008258:269806:280503280503281159657Shigella flexneri 5 str. 8401, complete genomeputative bacteriophage protein7e-30129
NC_002655:1332961:133493113349311335704774Escherichia coli O157:H7 EDL933, complete genomeunknown protein encoded by bacteriophage BP-933W5e-2096.7
NC_013361:3287671:330152033015203302188669Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein3e-1994
NC_013353:5361207:536932553693255370095771Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein1e-1891.7
AP010958:5361207:536932553693255370095771Escherichia coli O103:H2 str. 12009 DNA, complete genomehypothetical protein1e-1891.7
NC_011601:1039500:104556610455661046234669Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein2e-1891.3
NC_016860:364981:371050371050371841792Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein4e-1890.1
NC_004431:1401681:140521014052101405668459Escherichia coli CFT073, complete genomehypothetical protein6e-1889.7
NC_013008:3231414:324461432446143245561948Escherichia coli O157:H7 str. TW14359 chromosome, complete genomehypothetical protein1e-1685.1
NC_011353:3276734:328974332897433290690948Escherichia coli O157:H7 str. EC4115 chromosome, complete genomehypothetical protein1e-1685.1
NC_013364:1183000:118766411876641188218555Escherichia coli O111:H- str. 11128, complete genomehypothetical protein1e-1582
NC_013364:2645438:265686626568662657420555Escherichia coli O111:H- str. 11128, complete genomehypothetical protein1e-1582
NC_007946:2625461:263614426361442636716573Escherichia coli UTI89, complete genomehypothetical protein2e-1581.3
NC_011601:717072:724147724147724785639Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein3e-1580.9
NC_011601:2614691:262714526271452627783639Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein3e-1580.9
NC_009800:289000:294476294476295159684Escherichia coli HS, complete genomehypothetical protein4e-1580.1
NC_011083:374000:380217380217380702486Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,protein ea224e-1477
AP010958:2911741:291625929162592916960702Escherichia coli O103:H2 str. 12009 DNA, complete genomehypothetical protein5e-1476.6
NC_013353:2911741:291625929162592916960702Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein5e-1476.6
NC_012947:3015985:302686930268693027417549Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein1e-1375.5
NC_013941:3300000:330852533085253309343819Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeenterohemolysin 22e-1374.7
NC_013361:1558423:156413515641351564542408Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein7e-1166.2
NC_011094:593100:603941603941604384444Salmonella enterica subsp. enterica serovar Schwarzengrund strhypothetical protein5e-0650.1