Pre_GI: BLASTP Hits

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Query: NC_017328:2785309:2797252 Shigella flexneri 2002017 chromosome, complete genome

Start: 2797252, End: 2797324, Length: 73

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011741:2818750:283036228303622830691330Escherichia coli IAI1 chromosome, complete genomehypothetical protein1e-0652
NC_011748:2973968:299614129961412996470330Escherichia coli 55989, complete genomehypothetical protein1e-0652
CU928145:2973968:299614129961412996470330Escherichia coli 55989 chromosome, complete genomeconserved hypothetical protein1e-0652
CU928160:2818750:283036228303622830691330Escherichia coli IAI1 chromosome, complete genomeconserved hypothetical protein1e-0652
NC_004741:2741971:27530032753003275307876Shigella flexneri 2a str. 2457T, complete genometRNA-Ile2e-0650.8
CU928145:2973968:29963772996377299645276Escherichia coli 55989 chromosome, complete genometRNA-Met2e-0650.8
NC_004337:2747917:27583672758367275844276Shigella flexneri 2a str. 301, complete genometRNA-Met2e-0650.8
NC_000913:2746886:27837842783784278385976Escherichia coli K12, complete genometRNA-Ile2e-0650.8
NC_008258:2905413:29108252910825291090076Shigella flexneri 5 str. 8401, complete genometRNA-Met2e-0650.8
NC_009800:2788164:28032072803207280328276Escherichia coli HS, complete genometRNA-Met2e-0650.8
NC_009801:2898426:29462862946286294636176Escherichia coli E24377A, complete genometRNA-Met2e-0650.8
NC_010468:1130000:11383331138333113840876Escherichia coli ATCC 8739, complete genometRNA-Met2e-0650.8
NC_007384:2933625:29454082945408294548376Shigella sonnei Ss046, complete genometRNA-Met2e-0650.8
AC_000091:2747520:27844182784418278449376Escherichia coli W3110 DNA, complete genometRNA-Ile2e-0650.8
NC_010473:2839902:28755492875549287562476Escherichia coli str. K-12 substr. DH10B, complete genometRNA-Ile2e-0650.8
NC_011748:2973968:29963772996377299645276Escherichia coli 55989, complete genometRNA-Met2e-0650.8
NC_011741:2818750:28305982830598283067376Escherichia coli IAI1 chromosome, complete genometRNA-Met2e-0650.8
NC_012759:2633949:26695962669596266967176Escherichia coli BW2952 chromosome, complete genometRNA-Ile2e-0650.8
NC_016822:3065426:30769783076978307705376Shigella sonnei 53G, complete genometRNA-Met2e-0650.8
CU928160:2818750:28305982830598283067376Escherichia coli IAI1 chromosome, complete genometRNA-Met2e-0650.8