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Query: NC_017328:2516000:2535392 Shigella flexneri 2002017 chromosome, complete genome

Start: 2535392, End: 2535667, Length: 276

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004741:2456297:247588824758882476163276Shigella flexneri 2a str. 2457T, complete genomehypothetical protein1e-38158
NC_010468:1412791:141611314161131416388276Escherichia coli ATCC 8739, complete genomehypothetical protein4e-38156
CP002185:2659628:267915426791542679429276Escherichia coli W, complete genomepredicted lipoprotein involved in colanic acid biosynthesis4e-38156
CP002516:1419413:142642814264281426703276Escherichia coli KO11, complete genomehypothetical protein4e-38156
CU928160:2513000:253160325316032531878276Escherichia coli IAI1 chromosome, complete genomeputative lipoprotein4e-38156
AP010958:2911741:294569229456922945967276Escherichia coli O103:H2 str. 12009 DNA, complete genomepredicted lipoprotein4e-38156
NC_007384:2587876:260785526078552608130276Shigella sonnei Ss046, complete genomehypothetical protein4e-38156
NC_011741:2513000:253160325316032531878276Escherichia coli IAI1 chromosome, complete genomehypothetical protein4e-38156
NC_012947:1363724:136704613670461367321276Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein4e-38156
NC_012967:2409500:242892224289222429197276Escherichia coli B str. REL606 chromosome, complete genomeputative lipoprotein involved in colanic acid biosynthesis4e-38156
NC_013353:2911741:294569229456922945967276Escherichia coli O103:H2 str. 12009, complete genomelipoprotein4e-38156
NC_016902:1419413:142642814264281426703276Escherichia coli KO11FL chromosome, complete genomehypothetical protein4e-38156
NC_007613:2376974:239662723966272396902276Shigella boydii Sb227, complete genomehypothetical protein6e-38155
NC_008253:2499735:251812625181262518401276Escherichia coli 536, complete genomehypothetical lipoprotein YpdI precursor4e-35146
NC_011601:2614691:265110626511062651381276Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomelipoprotein involved in colanic acid biosynthesis4e-35146
NC_011745:2751437:276943627694362769711276Escherichia coli ED1a chromosome, complete genomeputative lipoprotein2e-34144
NC_008563:2610499:262850226285022628777276Escherichia coli APEC O1, complete genomeputative lipoprotein involved in colanic acid biosynthesis2e-33140
NC_013941:2928000:296394929639492964176228Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein3e-32136
NC_007606:2353098:237192423719242372199276Shigella dysenteriae Sd197, complete genomehypothetical protein2e-26117