Pre_GI: BLASTP Hits

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Query: NC_017328:2090679:2109097 Shigella flexneri 2002017 chromosome, complete genome

Start: 2109097, End: 2109453, Length: 357

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004741:2009769:203017120301712030527357Shigella flexneri 2a str. 2457T, complete genomehypothetical bacteriophage protein1e-65248
NC_004337:2035945:205483820548382055194357Shigella flexneri 2a str. 301, complete genomehypothetical bacteriophage protein1e-65248
NC_007946:2894793:291553329155332915889357Escherichia coli UTI89, complete genomehypothetical protein2e-54210
NC_009436:2776410:279721827972182797574357Enterobacter sp. 638, complete genomehypothetical protein1e-53207
NC_010102:1779707:180957718095771809933357Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein2e-51200
NC_011094:2115750:213697421369742137330357Salmonella enterica subsp. enterica serovar Schwarzengrund strtail tube protein2e-51200
NC_011205:2137696:215831521583152158671357Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853tail tube protein2e-51200
NC_011294:2009388:203000920300092030365357Salmonella enterica subsp. enterica serovar Enteritidis strphage tail tube protein2e-51200
NC_007712:1182518:120194112019411202309369Sodalis glossinidius str. 'morsitans', complete genomehypothetical protein7e-46182
NC_020260:1615135:164642816464281646784357Cronobacter sakazakii Sp291, complete genomebacteriophage tail tube protein2e-42171
NC_002937:2933000:295837629583762958741366Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completetail tube protein, putative8e-0855.8