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Query: NC_017328:2090679:2108762 Shigella flexneri 2002017 chromosome, complete genome

Start: 2108762, End: 2109097, Length: 336

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004741:2009769:202983620298362030171336Shigella flexneri 2a str. 2457T, complete genomehypothetical bacteriophage protein6e-60229
NC_004337:2035945:205450320545032054838336Shigella flexneri 2a str. 301, complete genomehypothetical bacteriophage protein6e-60229
NC_011294:2009388:202968620296862030012327Salmonella enterica subsp. enterica serovar Enteritidis strphage protein2e-36150
NC_011205:2137696:215799221579922158318327Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853hypothetical protein2e-36150
NC_010102:1779707:180925418092541809580327Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein2e-36150
NC_011094:2115750:213665121366512136977327Salmonella enterica subsp. enterica serovar Schwarzengrund strhypothetical protein9e-36148
NC_020260:1615135:164678116467811647107327Cronobacter sakazakii Sp291, complete genomeSb154e-29126
NC_007712:1182518:120162112016211201944324Sodalis glossinidius str. 'morsitans', complete genomehypothetical protein2e-23107
NC_009436:2776410:279694927969492797218270Enterobacter sp. 638, complete genomebacteriophage protein1e-1272
NC_007946:2894793:291526429152642915533270Escherichia coli UTI89, complete genomehypothetical protein2e-1271.2