Pre_GI: BLASTP Hits

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Query: NC_017328:2090679:2103953 Shigella flexneri 2002017 chromosome, complete genome

Start: 2103953, End: 2104330, Length: 378

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011353:1761977:178209217820921782262171Escherichia coli O157:H7 str. EC4115 chromosome, complete genome8e-1165.9
NC_004337:2035945:204969420496942050071378Shigella flexneri 2a str. 301, complete genomehypothetical bacteriophage protein2e-57220
NC_008258:2045000:205701920570192057396378Shigella flexneri 5 str. 8401, complete genomehypothetical bacteriophage protein2e-51200
NC_004741:2009769:202502820250282025405378Shigella flexneri 2a str. 2457T, complete genomehypothetical bacteriophage protein2e-57220
NC_007384:1320287:134525713452571345880624Shigella sonnei Ss046, complete genomehypothetical bacteriophage protein1e-53207
NC_011745:1055354:107370310737031074281579Escherichia coli ED1a chromosome, complete genomehypothetical protein1e-1168.2
AP010958:1472506:149081514908151491123309Escherichia coli O103:H2 str. 12009 DNA, complete genomehypothetical protein2e-1374.7
NC_011745:2025725:202831720283172028892576Escherichia coli ED1a chromosome, complete genomehypothetical protein1e-1065.1
NC_013008:1761165:178093017809301781238309Escherichia coli O157:H7 str. TW14359 chromosome, complete genomehypothetical protein2e-1374.7
NC_013353:1472506:149081514908151491123309Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein2e-1374.7
NC_011147:1057259:106444610644461065432987Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein4e-1166.6
NC_011080:1166951:117451911745191175157639Salmonella enterica subsp. enterica serovar Newport str. SL254,phage tail assembly protein9e-1062.4
NC_007613:1038000:104351710435171044140624Shigella boydii Sb227, complete genomeputative tail component of prophage1e-56218
NC_016822:1304398:132809813280981328721624Shigella sonnei 53G, complete genometail component of prophage1e-56218