Pre_GI: BLASTP Hits

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Query: NC_017297:3939328:3977127 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 3977127, End: 3978275, Length: 1149

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:3940984:3979431397943139805791149Clostridium botulinum F str. Langeland chromosome, complete genomeR-2-hydroxyglutaryl-CoA dehydratase subunit0780
NC_009495:3832500:3870956387095638721041149Clostridium botulinum A str. ATCC 3502 chromosome, complete genome2-hydroxyacyl-CoA dehydratase subunit beta0777
NC_010516:3903867:3942313394231339434611149Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit0776
NC_010520:3526883:3532463353246335336111149Clostridium botulinum A3 str. Loch Maree, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit9e-143506
NC_017297:3546467:3546467354646735476151149Clostridium botulinum F str. 230613 chromosome, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit1e-141502
NC_010468:4059436:4081205408120540823561152Escherichia coli ATCC 8739, complete genome2-hydroxyglutaryl-CoA dehydratase D-component3e-128458
NC_012759:4501206:4501206450120645023571152Escherichia coli BW2952 chromosome, complete genomeputative 2-hydroxyglutaryl-CoA dehydratase4e-128457
AC_000091:4569379:4569379456937945705301152Escherichia coli W3110 DNA, complete genomepredicted 2-hydroxyglutaryl-CoA dehydratase4e-128457
NC_015589:2846000:2868226286822628693801155Desulfotomaculum ruminis DSM 2154 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase D-component1e-109396
NC_010337:147664:1783951783951795701176Heliobacterium modesticaldum Ice1, complete genome2-hydroxyglutaryl-coa dehydratase subunit9e-99360
NC_012108:904260:9042609042609053931134Desulfobacterium autotrophicum HRM2, complete genomeputative (R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit1e-82306
NC_013887:189400:2036122036122047541143Methanocaldococcus sp. FS406-22 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase D-component1e-79297
NC_015562:1189111:1215101121510112162191119Methanotorris igneus Kol 5 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase D-component3e-75282
NC_010520:3526883:3531075353107535323341260Clostridium botulinum A3 str. Loch Maree, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit4e-74278
NC_007519:64157:8277382773840531281Desulfovibrio alaskensis G20 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase subunit beta-like4e-68258
NC_011830:1190502:1191815119181511929541140Desulfitobacterium hafniense DCB-2, complete genome2-hydroxyglutaryl-CoA dehydratase D-component8e-38158
NC_014828:2038692:2081044208104420822761233Ethanoligenens harbinense YUAN-3 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase D-component3e-32139
NC_011832:1148859:1177120117712011783011182Candidatus Methanosphaerula palustris E1-9c, complete genome2-hydroxyglutaryl-CoA dehydratase D-component3e-29129
NC_009699:3581376:3589096358909635902201125Clostridium botulinum F str. Langeland chromosome, complete genomeR-phenyllactate dehydratase subunit C6e-2099
NC_009697:3463736:3471452347145234725761125Clostridium botulinum A str. ATCC 19397 chromosome, completeR-phenyllactate dehydratase subunit C5e-2099
NC_009698:3359766:3368560336856033696841125Clostridium botulinum A str. Hall chromosome, complete genomeR-phenyllactate dehydratase subunit C5e-2099
NC_010516:3545017:3556372355637235574961125Clostridium botulinum B1 str. Okra, complete genomeR-phenyllactate dehydratase, C subunit6e-2098.6
NC_012563:3729817:3737520373752037386441125Clostridium botulinum A2 str. Kyoto, complete genomeR-phenyllactate dehydratase, C subunit4e-1995.9
NC_012658:2393427:2403727240372724048541128Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative (R)-2-hydroxyglutaryl-CoA dehydratase subunit beta2e-1790.5
NC_009697:2265409:2276098227609822772251128Clostridium botulinum A str. ATCC 19397 chromosome, completeR-2-hydroxyglutaryl-CoA dehydratase subunit beta2e-1790.5
NC_009698:2265475:2276164227616422772911128Clostridium botulinum A str. Hall chromosome, complete genomeR-2-hydroxyglutaryl-CoA dehydratase subunit beta2e-1790.5
NC_017179:446564:4546784546784558051128Clostridium difficile BI1, complete genomeoxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase subunit3e-1790.1
NC_013315:435599:4451154451154462421128Clostridium difficile CD196 chromosome, complete genomesubunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase3e-1790.1
NC_010516:2374000:2384211238421123853381128Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase, beta subunit9e-1788.2
NC_012563:2466000:2476322247632224774491128Clostridium botulinum A2 str. Kyoto, complete genome(R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit2e-1686.7
NC_009943:1043210:1043210104321010443311122Candidatus Desulfococcus oleovorans Hxd3, complete genome2-hydroxyglutaryl-CoA dehydratase D-component7e-1685.5
NC_003454:822804:8351088351088362561149Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete(R)-2-hydroxyglutaryl-CoA dehydratase beta-subunit5e-1168.9
NC_007503:1047577:1053400105340010546081209Carboxydothermus hydrogenoformans Z-2901, complete genomeputative (R)-2-hydroxyglutaryl-CoA dehydratase, alpha subunit3e-0859.7
NC_015172:1002872:1002872100287210042631392Syntrophobotulus glycolicus DSM 8271 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase D-component1e-0758.2
NC_012658:2393427:2410751241075124124421692Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative CoA-substrate-specific enzyme activase2e-0654.3
NC_012563:2466000:2483195248319524848861692Clostridium botulinum A2 str. Kyoto, complete genomebenzoyl-CoA reductase, subunit A2e-0654.3
NC_009697:2265409:2283125228312522848191695Clostridium botulinum A str. ATCC 19397 chromosome, completeR-2-hydroxyglutaryl-CoA dehydratase subunit/ R-2-hydroxyglutaryl-CoA dehydratase activase3e-0653.5
NC_011832:1148859:1167636116763611691201485Candidatus Methanosphaerula palustris E1-9c, complete genome2-hydroxyglutaryl-CoA dehydratase D-component3e-0653.1
NC_010516:2374000:2391090239109023927841695Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit/putative R-2-hydroxyglutaryl-CoA dehydratase activase3e-0653.1
NC_014828:2038692:2078637207863720798871251Ethanoligenens harbinense YUAN-3 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase D-component3e-0653.1