Pre_GI: BLASTP Hits

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Query: NC_017297:3939328:3975549 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 3975549, End: 3975866, Length: 318

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:3940984:397785339778533978170318Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein3e-52203
NC_009698:3706154:374302237430223743339318Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein3e-52203
NC_009495:3832500:386937838693783869695318Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein3e-52203
NC_010516:3903867:394073539407353941052318Clostridium botulinum B1 str. Okra, complete genomehypothetical protein3e-52203
NC_010520:3938490:397538539753853975702318Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein3e-52203
NC_011837:3814000:387977138797713880088318Clostridium kluyveri NBRC 12016, complete genomehypothetical protein5e-41166
NC_009706:3882500:394826839482683948585318Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein5e-41166