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Query: NC_017297:3939328:3963057 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 3963057, End: 3963242, Length: 186

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:3940984:396536239653623965547186Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-28124
NC_009698:3706154:373052837305283730713186Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein2e-28124
NC_009495:3832500:385688438568843857069186Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-28124
NC_010520:3938490:396287639628763963061186Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein2e-28124
NC_010516:3903867:392823739282373928422186Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-28124
NC_010001:3473425:3486359348635934882241866Clostridium phytofermentans ISDg, complete genomehybrid cluster protein9e-1062.4
NC_010001:4586000:460532646053264605526201Clostridium phytofermentans ISDg, complete genomeconserved hypothetical protein, CF-27 family2e-0961.6
NC_015873:1193843:119903311990331199275243Megasphaera elsdenii DSM 20460, complete genomehypothetical protein1e-0961.6
NC_014376:317312:339912339912340112201Clostridium saccharolyticum WM1 chromosome, complete genomeDomain of unknown function DUF18582e-0961.2
NC_011898:2907017:292312629231262923329204Clostridium cellulolyticum H10, complete genomeDomain of unknown function DUF18584e-0960.1
NC_012918:2668031:268416226841622684356195Geobacter sp. M21 chromosome, complete genomehypothetical protein5e-0856.6
NC_011146:2200142:220410222041022204296195Geobacter bemidjiensis Bem, complete genomehypothetical protein5e-0856.6