Pre_GI: BLASTP Hits

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Query: NC_017297:3752000:3759063 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 3759063, End: 3759458, Length: 396

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:3753599:376045037604503760845396Clostridium botulinum F str. Langeland chromosome, complete genomeglucitol operon activator protein1e-63241
NC_010516:3724312:372867137286713729066396Clostridium botulinum B1 str. Okra, complete genomeglucitol operon activator protein1e-63241
NC_010520:3753875:375818537581853758580396Clostridium botulinum A3 str. Loch Maree, complete genomeglucitol operon activator protein8e-62234
NC_012658:3744000:374853337485333748928396Clostridium botulinum Ba4 str. 657 chromosome, complete genomeglucitol operon activator protein4e-61233
NC_012563:3921859:392552239255223925917396Clostridium botulinum A2 str. Kyoto, complete genomeglucitol operon activator protein5e-61232
NC_009698:3526359:353071735307173531112396Clostridium botulinum A str. Hall chromosome, complete genomeglucitol operon activator protein2e-60230
NC_009697:3629250:363360836336083634003396Clostridium botulinum A str. ATCC 19397 chromosome, completeglucitol operon activator protein2e-60230
NC_015519:686027:688825688825689217393Tepidanaerobacter sp. Re1 chromosome, complete genomeglucitol operon activator1e-1374.7
NC_017316:2710021:271057527105752711060486Enterococcus faecalis OG1RF chromosome, complete genometranscriptional regulator SrlR3e-1373.9
NC_004668:3184319:318894431889443189429486Enterococcus faecalis V583, complete genometranscriptional regulator SrlR3e-1373.9
NC_014377:1400544:140392014039201404285366Thermosediminibacter oceani DSM 16646 chromosome, complete genomeGlucitol operon activator5e-1373.2
NC_015389:1782825:179144617914461791955510Coriobacterium glomerans PW2 chromosome, complete genomeGlucitol operon activator1e-1271.6
NC_007930:180281:184097184097184594498Lactobacillus salivarius subsp. salivarius UCC118 plasmid pMP118,Sorbitol operon activator4e-1166.6
NC_015637:891842:894712894712895068357Vibrio anguillarum 775 chromosome chromosome II, complete sequenceglucitol operon activator protein2e-0857.8
NC_016818:3986570:399991439999144000276363Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completeglucitol operon activator2e-0651.2