Pre_GI: BLASTP Hits

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Query: NC_017297:3594000:3604382 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 3604382, End: 3605875, Length: 1494

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:3581376:3605767360576736072601494Clostridium botulinum F str. Langeland chromosome, complete genome[Fe] hydrogenase0959
NC_009495:3502000:3512133351213335136291497Clostridium botulinum A str. ATCC 3502 chromosome, complete genome[Fe] hydrogenase0954
NC_009697:3463736:3488121348812134896141494Clostridium botulinum A str. ATCC 19397 chromosome, complete[Fe] hydrogenase0954
NC_010520:3580000:3589336358933635908291494Clostridium botulinum A3 str. Loch Maree, complete genome[Fe] hydrogenase0946
NC_012563:3729817:3754207375420737557001494Clostridium botulinum A2 str. Kyoto, complete genome[Fe] hydrogenase0937
NC_004557:2552418:2556219255621925577031485Clostridium tetani E88, complete genomeperiplasmic [Fe] hydrogenase 15e-165581
NC_015425:2389400:2403109240310924045931485Clostridium botulinum BKT015925 chromosome, complete genomeFe-hydrogenase large subunit family protein2e-164579
NC_008593:2136759:2146548214654821480321485Clostridium novyi NT, complete genomeFe-hydrogenase large subunit family protein1e-163576
NC_020291:491000:5095775095775110641488Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeferredoxin hydrogenase2e-148525
NC_009617:385000:3941173941173956071491Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeferredoxin hydrogenase1e-147523
NC_010723:371741:3830613830613845451485Clostridium botulinum E3 str. Alaska E43, complete genomeiron-dependent hydrogenase2e-145515
NC_010674:370629:3876673876673891511485Clostridium botulinum B str. Eklund 17B, complete genomeiron-dependent hydrogenase8e-145514
NC_015958:1983815:2002191200219120037321542Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehydrogenase large subunit domain-containing protein7e-115414
NC_010001:109893:1200331200331214871455Clostridium phytofermentans ISDg, complete genomeFerredoxin hydrogenase3e-96352
NC_014824:133065:1464801464801479161437Ruminococcus albus 7 plasmid pRUMAL01, complete sequencehydrogenase large subunit domain protein2e-90333
NC_010424:448865:4541674541674556241458Candidatus Desulforudis audaxviator MP104C, complete genomehydrogenase large subunit domain protein3e-79296
NC_014364:3500041:3519450351945035209641515Spirochaeta smaragdinae DSM 11293 chromosome, complete genomehydrogenase large subunit domain protein7e-77288
NC_013203:472679:4744474744474760421596Atopobium parvulum DSM 20469, complete genomeFerredoxin hydrogenase2e-76286
NC_006138:2683545:2717282271728227187331452Desulfotalea psychrophila LSv54, complete genomesimilar to hydrogenase7e-73275
NC_015389:1298689:1320798132079813223511554Coriobacterium glomerans PW2 chromosome, complete genomehydrogenase large subunit domain protein3e-70266
NC_010644:485966:5097615097615111971437Elusimicrobium minutum Pei191, complete genomehydrogenase large subunit5e-68258
NC_014328:2203437:2203437220343722047831347Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative Iron only hydrogenase large subunit5e-50199
NC_009698:3647955:3669220366922036705691350Clostridium botulinum A str. Hall chromosome, complete genome[Fe] hydrogenase6e-47188
NC_010516:3845942:3867259386725938686081350Clostridium botulinum B1 str. Okra, complete genome[Fe] hydrogenase2e-46187
NC_020134:2832857:2836197283619728375851389Clostridium stercorarium subsp. stercorarium DSM 8532, completehydrogenase large subunit domain protein2e-46186
NC_008261:304000:3265183265183278671350Clostridium perfringens ATCC 13124, complete genome[Fe] hydrogenase3e-45183
NC_008262:297960:3212573212573226061350Clostridium perfringens SM101, complete genomeHydrogenase subunit (ferredoxin)2e-43177
NC_007907:960104:9669189669189681951278Desulfitobacterium hafniense Y51, complete genomehypothetical protein3e-43176
NC_019978:7535:2927929279309671689Halobacteroides halobius DSM 5150, complete genomeiron only hydrogenase large subunit2e-27124
NC_015519:2605709:2613464261346426154431980Tepidanaerobacter sp. Re1 chromosome, complete genomehydrogenase, Fe-only8e-26119
NC_010001:109893:1154371154371171401704Clostridium phytofermentans ISDg, complete genomehydrogenase, Fe-only5e-26119
NC_007503:1383255:1383255138325513854532199Carboxydothermus hydrogenoformans Z-2901, complete genomesigma-54 dependent transcriptional regulator8e-25115
NC_008261:2920999:2926027292602729277451719Clostridium perfringens ATCC 13124, complete genomeiron hydrogenase1e-24114
NC_016584:3826300:3826300382630038291252826Desulfosporosinus orientis DSM 765 chromosome, complete genomesignal transduction histidine kinase3e-23110
NC_010334:1701957:1701957170195717031891233Shewanella halifaxensis HAW-EB4, complete genomehydrogenase, Fe-only8e-23108
NC_019978:2260395:2284480228448022862071728Halobacteroides halobius DSM 5150, complete genomehydrogenase, Fe-only1e-22108
NC_015589:2555000:2555101255510125568131713Desulfotomaculum ruminis DSM 2154 chromosome, complete genomePAS fold domain-containing protein6e-22105
NC_014377:532816:5487185487185504181701Thermosediminibacter oceani DSM 16646 chromosome, complete genomeNAD(P)-dependent iron-only hydrogenase catalytic subunit9e-22105
NC_011830:2177187:2194046219404621974983453Desulfitobacterium hafniense DCB-2, complete genomehydrogenase, Fe-only9e-22105
NC_016048:1602500:1603093160309316047871695Oscillibacter valericigenes Sjm18-20, complete genomeputative uptake hydrogenase subunit HupA1e-20101
NC_016012:879972:8821658821658839011737Candidatus Arthromitus sp. SFB-rat-Yit, complete genomeiron hydrogenase2e-20100
NC_013740:2141523:2158428215842821601581731Acidaminococcus fermentans DSM 20731, complete genomehydrogenase, Fe-only3e-20100
NC_014824:133065:1436251436251453011677Ruminococcus albus 7 plasmid pRUMAL01, complete sequenceputative PAS/PAC sensor protein6e-2099.4
NC_013385:1758383:1776695177669517784311737Ammonifex degensii KC4, complete genomehydrogenase, Fe-only7e-2099
NC_007519:64157:7582175821770861266Desulfovibrio alaskensis G20 chromosome, complete genomeferredoxin hydrogenase2e-1997.8
NC_015578:1038588:1043196104319610449471752Treponema primitia ZAS-2 chromosome, complete genomeferredoxin 23e-1997.1
NC_012778:207415:2259602259602276421683Eubacterium eligens ATCC 27750, complete genomeNADH dehydrogenase I chain G1e-1895.1
NC_010320:671699:6831316831316848731743Thermoanaerobacter sp. X514 chromosome, complete genomeputative PAS/PAC sensor protein3e-1893.6
NC_010321:244371:2530382530382547711734Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completehydrogenase3e-1893.6
NC_013385:1758383:1778719177871917804701752Ammonifex degensii KC4, complete genomehydrogenase, Fe-only1e-1792
NC_020291:2701149:2703814270381427051871374Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome[FeFe] hydrogenase, group A1e-1791.7
NC_015958:1983815:1989439198943919911661728Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeputative PAS/PAC sensor protein1e-1791.7
NC_016627:1485799:1518304151830415200791776Clostridium clariflavum DSM 19732 chromosome, complete genomehydrogenase, Fe-only2e-1790.9
NC_004663:107019:1132011132011149671767Bacteroides thetaiotaomicron VPI-5482, complete genomeNADH:ubiquinone oxidoreductase subunit3e-1790.5
NC_015425:2072703:2098141209814121000301890Clostridium botulinum BKT015925 chromosome, complete genometranscriptional regulator2e-1687.4
NC_011837:830436:8416928416928430921401Clostridium kluyveri NBRC 12016, complete genomehypothetical protein5e-1686.3
NC_009706:830461:8417448417448431171374Clostridium kluyveri DSM 555 chromosome, complete genomeFe-Fe hydrogenase 26e-1685.9
NC_015949:2327500:2327610232761023294811872Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomemethyl-accepting chemotaxis sensory transducer1e-1585.1
NC_010001:109893:1227551227551244881734Clostridium phytofermentans ISDg, complete genomeputative PAS/PAC sensor protein3e-1583.6
NC_014328:773095:7859367859367873241389Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeFe-Fe hydrogenase 29e-1582
NC_016627:1485799:1512139151213915134731335Clostridium clariflavum DSM 19732 chromosome, complete genomeiron only hydrogenase large subunit5e-1479.7
NC_013315:3689422:3708153370815337095291377Clostridium difficile CD196 chromosome, complete genomehydrogenase5e-1376.3
NC_014328:2203437:2216007221600722179231917Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcriptional regulator3e-1067
NC_014632:11925:2504825048260521005Ilyobacter polytropus DSM 2926 chromosome, complete genomeRnfABCDGE type electron transport complex subunit B1e-0758.5
NC_013156:154233:1542331542331553001068Methanocaldococcus fervens AG86, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein1e-0758.2
NC_000916:1417981:1421167142116714221771011Methanothermobacter thermautotrophicus str. Delta H, completetungsten formylmethanofuran dehydrogenase, subunit F3e-0757
NC_009635:1283830:1287142128714212883381197Methanococcus aeolicus Nankai-3 chromosome, complete genome4Fe-4S ferredoxin2e-0654.3
NC_015574:143000:1473171473171483811065Methanobacterium sp. SWAN-1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein3e-0653.9
NC_009012:1857845:1874604187460418757371134Clostridium thermocellum ATCC 27405, complete genome4Fe-4S ferredoxin, iron-sulfur binding3e-0653.9
NC_013156:226215:2355912355912367631173Methanocaldococcus fervens AG86, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein2e-0653.9
NC_013790:485468:4936794936794947821104Methanobrevibacter ruminantium M1 chromosome, complete genometungsten formylmethanofuran dehydrogenase subunit F FwdF4e-0653.1
NC_015216:2548057:2556787255678725578301044Methanobacterium sp. AL-21 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein5e-0653.1
NC_012623:160224:159958159958160227270Sulfolobus islandicus Y.N.15.51 chromosome, complete genome4Fe-4S ferredoxin7e-0652.8
NC_013887:245236:276610276610277101492Methanocaldococcus sp. FS406-22 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein6e-0652.8
NC_003551:415803:4276864276864288251140Methanopyrus kandleri AV19, complete genomeFerredoxin6e-0652.8
NC_012726:2338500:234749023474902347759270Sulfolobus islandicus M.16.4 chromosome, complete genome4Fe-4S ferredoxin6e-0652.8
NC_017276:2240069:223980322398032240072270Sulfolobus islandicus REY15A chromosome, complete genome4Fe-4S ferredoxin6e-0652.8
NC_009515:1409912:1435222143522214363191098Methanobrevibacter smithii ATCC 35061, complete genometungsten formylmethanofuran dehydrogenase, subunit F, FwdF6e-0652.8
NC_009975:917337:9285489285489297351188Methanococcus maripaludis C6, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein8e-0652.4