Pre_GI: BLASTP Hits

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Query: NC_017297:3594000:3602557 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 3602557, End: 3603201, Length: 645

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:3581376:360394136039413604585645Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein8e-73273
NC_012563:3729817:375238137523813753025645Clostridium botulinum A2 str. Kyoto, complete genomeintegral membrane protein TIGR019067e-72270
NC_009697:3463736:348629534862953486939645Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein1e-71269
NC_009495:3502000:351030735103073510951645Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-71269
NC_010520:3580000:358817935881793588823645Clostridium botulinum A3 str. Loch Maree, complete genomeintegral membrane protein TIGR019062e-68258
NC_004557:2552418:255468325546832555321639Clostridium tetani E88, complete genomemembrane spanning protein3e-26118
NC_005945:1459357:146087214608721461558687Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-21102
NC_007530:1459412:146091814609181461604687Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-21102
NC_014393:3650957:365335536533553653984630Clostridium cellulovorans 743B chromosome, complete genomeintegral membrane protein TIGR019063e-21101
NC_021182:1473535:148854114885411489209669Clostridium pasteurianum BC1, complete genomeintegral membrane protein TIGR019067e-2097.1
NC_010723:3530000:353746035374603538140681Clostridium botulinum E3 str. Alaska E43, complete genomeintegral membrane protein8e-1373.9
NC_014334:769205:770640770640771263624Lactobacillus casei str. Zhang chromosome, complete genomehypothetical protein2e-1272.4
NC_008262:2498000:250201825020182502668651Clostridium perfringens SM101, complete genomeintegral membrane protein3e-1272
NC_013198:813830:818158818158818790633Lactobacillus rhamnosus GG, complete genomeconserved hypothetical protein (integral membrane protein by homology)4e-1271.2
NC_010999:880878:881660881660882283624Lactobacillus casei, complete genomePutative uncharacterized protein ylfI4e-1271.2
NC_008526:817628:819063819063819686624Lactobacillus casei ATCC 334, complete genomePredicted membrane protein4e-1271.2
NC_013199:811929:812706812706813338633Lactobacillus rhamnosus Lc 705, complete genomeconserved hypothetical protein (integral membrane protein by homology)2e-1169.3
NC_010674:3674739:368027836802783680958681Clostridium botulinum B str. Eklund 17B, complete genomeintegral membrane protein4e-1168.2
NC_012470:853561:856218856218856859642Streptococcus equi subsp. zooepidemicus, complete genomemembrane protein6e-1064.3
NC_016605:766836:771932771932772564633Pediococcus claussenii ATCC BAA-344 chromosome, complete genomehypothetical protein8e-0960.5
NC_011134:1222739:123839712383971239044648Streptococcus equi subsp. zooepidemicus str. MGCS10565, completehypothetical membrane spanning protein1e-0859.7
NC_014727:1537183:155327615532761553881606Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,membrane protein5e-0754.7
NC_010080:445398:448172448172448780609Lactobacillus helveticus DPC 4571, complete genomeputative membrane protein5e-0754.3
NC_018528:446610:452265452265452873609Lactobacillus helveticus R0052 chromosome, complete genomeMembrane protein2e-0652.4