Pre_GI: BLASTP Hits

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Query: NC_017297:3178378:3196603 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 3196603, End: 3196998, Length: 396

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:3178222:319644831964483196843396Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein4e-68256
NC_009697:3071198:308881030888103089205396Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein1e-66251
NC_009495:3138355:315596731559673156362396Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-66251
NC_012563:3374904:339251633925163392911396Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-66251
NC_010516:3196158:321390232139023214297396Clostridium botulinum B1 str. Okra, complete genomehypothetical protein4e-66249
NC_010520:3204480:322222332222233222618396Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein5e-66248
NC_012658:3213498:323129332312933231688396Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein5e-65245