Pre_GI: BLASTP Hits

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Query: NC_017297:2143000:2153431 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 2153431, End: 2154723, Length: 1293

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:2142177:2153332215333221546241293Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein0815
NC_010516:2093901:2103098210309821043901293Clostridium botulinum B1 str. Okra, complete genomehypothetical protein0815
NC_009698:2012500:2023850202385020251421293Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein0809
NC_009697:2012500:2023633202363320249251293Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein0809
NC_009495:2085000:2094992209499220962841293Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein0809
NC_012563:2230403:2241701224170122429901290Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein0805
NC_012658:2138791:2149723214972321510121290Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein0803
NC_009089:3782000:3783072378307237843551284Clostridium difficile 630, complete genomehypothetical protein2e-72273
NC_018870:2479114:2486924248692424882431320Thermacetogenium phaeum DSM 12270 chromosome, complete genomeserine dehydratase-like, subunit alpha4e-70265
NC_014933:3942156:3962382396238239636651284Bacteroides helcogenes P 36-108 chromosome, complete genomeinner membrane protein9e-62238
NC_021066:3703725:3711465371146537127751311Raoultella ornithinolytica B6, complete genomehypothetical protein7e-58224
NC_018515:4196409:4206266420626642075731308Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein2e-56219
NC_003366:981105:9901919901919914741284Clostridium perfringens str. 13, complete genomehypothetical protein6e-56218
NC_015311:365007:3802283802283815171290Prevotella denticola F0289 chromosome, complete genomehypothetical protein2e-55217
NC_008262:904000:9168959168959181781284Clostridium perfringens SM101, complete genomehypothetical protein2e-54213
NC_014618:586240:6143916143916157011311Enterobacter cloacae SCF1 chromosome, complete genomehypothetical protein1e-52207
NC_014364:2904443:2907783290778329090841302Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeprotein of unknown function DUF10632e-52206
NC_011751:3710786:3710786371078637120961311Escherichia coli UMN026 chromosome, complete genomehypothetical protein3e-50199
NC_016077:2044876:2048537204853720498771341Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein4e-50199
NC_011748:3608917:3608917360891736102271311Escherichia coli 55989, complete genomehypothetical protein9e-50197
CU928145:3608917:3608917360891736102271311Escherichia coli 55989 chromosome, complete genomeconserved hypothetical protein9e-50197
NC_012947:630757:6508556508556521651311Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein2e-49197
NC_011750:3768692:3768692376869237700021311Escherichia coli IAI39 chromosome, complete genomehypothetical protein2e-49197
NC_011415:3523364:3523364352336435246741311Escherichia coli SE11 chromosome, complete genomehypothetical protein2e-49196
NC_002695:3994970:3994970399497039962801311Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein2e-49196
NC_013941:3884725:3884725388472538860351311Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein2e-49196
NC_010658:3014371:3031259303125930325691311Shigella boydii CDC 3083-94, complete genomehypothetical protein6e-49195
NC_015873:380485:4054994054994068181320Megasphaera elsdenii DSM 20460, complete genomeUPF0597 protein HMPREF0889_14069e-44177
NC_016630:1610723:1621430162143016226651236Filifactor alocis ATCC 35896 chromosome, complete genomeinner membrane protein1e-43177
NC_012785:638000:6431456431456444131269Kosmotoga olearia TBF 19.5.1, complete genomeprotein of unknown function DUF10632e-42173
NC_012779:2957000:2971262297126229725571296Edwardsiella ictaluri 93-146, complete genomehypothetical protein6e-42172
NC_016048:4163225:4166769416676941680461278Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-34147
NC_015500:159199:1626371626371639261290Treponema brennaborense DSM 12168 chromosome, complete genomeUPF0597 protein yhaM1e-27124